SCIENTIFIC PUBLICATIONS
Articles
ALS driven by mutant NEK1 aggregation is accelerated by Pml loss, but clinically reversed through pharmacologic induction of Pml-mediated degradation. P. Georgiadou, B. Erkaya, M. Kawakita, E. Sahin, H. Öztürk, F. Tiryaki, K. Yildiz, I. Özgenç, E. Pekbilir, S. Anil Dogan, V. Lallemand-Breitenbach, S. Vargas, A. Prochiantz, E. Nur Firat-Karalar, H. de Thé, U. Sahin (2025).
bioRXiv ;https://doi.org/10.1101/2024.11.23.622051
Motor recovery through perineuronal net modulation in a Parkinson’s Disease mouse model.
D. Benacom, C. Chataing, A. Prochiantz, A.A. Di Nardo (2025).
Brain, in press; https://doi.org/10.1093/brain/awaf226
Plasticity state-dependent changes in visual cortex parvalbumine interneuron mRNA translation and chromatin.
D. Benacom, C. Chataing, J. Apulei, I. Queguiner, A. Prochiantz & A.A. Di Nardo (2023).
bioRxiv; https://doi.org/10.1101/2023.09.11.557035
ENGRAILED-1 transcription factor exerts a paracrine neurotrophic activity on adultspinalord α-motoneurons.
M. Lebœuf, S.E. Vargas-Abonce, E.Pezé-Hedsieck, E. Dupont,Jimenez-Alonso, K. L. Moya & Alain Prochiantz (2022).
bioR; https://doi.org/10.1101/2022.08.16.504081
Perturbed DNA methylation by Gadd45b induces chromatin disorganization, DNA strand breaks and dopaminergic neuron death.
C. Ravel-Godreuil, O. Massiani-Beaudouin, P. Mailly, A. Prochiantz, R.L. Joshi & J. Fuchs (2021).
iScience; https://doi.org/10.1016/j.isci.2021.102756
Choroid plexus APP regulates adult brain proliferation and animal behavior.
K. Arnaud, V. Oliveira Moreira, J. Vincent, G. Dallerac, C. Le Poupon, M. Richter, U.C. Müller, L. Rondi-Reig, A. Prochiantz & A. Di Nardo (2021).
Life Sci. All.; https://pubmed.ncbi.nlm.nih.gov/34544751/
Non-cell autonomous OTX2 transcription factor regulates anxiety-related behaviors in the mouse. C. Vincent, J. Gilabert-Juan, D. Alvarez-Fischer, M.O. Krebs, G. Le Pen, A. Prochiantz & AA. Di Nardo (2021).
Mol.Psych.; https://pubmed.ncbi.nlm.nih.gov/33963285/
Diurrnal changes in perineuronal nets and parvalbumin neurons in rat prefrontal cortex. Brain structure and Function. J.H. Harkness, A.E. Gonzales, P.N. Bushana, E.T. Jorgensen, D.M. Hegarty, A.A. Di Nardo, A. Prochiantz, J.P. Wisor, S.A. Aicher, T.E. Brown & B.A. Sorg (2021).
Brain Struct. and Funct.; https://link.springer.com/article/10.1007/s00429-021-02229-4
Photoreceptor cKO of OTX2 enhances OTX2 intercellular transfer in the retina and causes photophobia. P. Pensieri, A. Mantilleri, D. Plassard, T. Furukawa, K.L. Moya, A. Prochiantz & T. Lamonerie (2021).
eNeuro; https://doi.org/10.1523/ENEURO.0229-21.2021
OTX2 stimulates adult retinal ganglion cell cell regeneration. R. Torero-Ibad, N. Quenech’du, A. Prochiantz & K.L. Moya (2021).
Neur. Regen. Res; https://doi.org/10.4103/1673-5374.320989
Extracellular Pax6 regulates tangential Cajal-Retzius cell migration in the developing mouse neocortex. H. Kaddour, E. Coppola, A. A. Di Nardo, A. Wizenmann, M. Volovitch, A. Prochiantz & A. Pierani (2020).
Cereb. Cortex; https://doi.org/10.1093/cercor/bhz098
OTX2 non-cell autonomous activity regulates inner retinal function. R. Torero-Ibad, B. Mazhar, C. Vincent, C. Bernard, J. Dégardin, M. Smonutti, T. Lamonerie, A.A. Di Nardo, A. Prochiantz & K.L. Moya (2020).
eNeuro; https://doi.org/10.1523/ENEURO.0012-19.2020
H2O2 and Engrailed 2 paracrine activity synergize to shape the zebrafish optic tectum. I. Amblard, M. Thauvin, C. Rampon, V.V. Park, A. Prochiantz, M. Volovitch, A. Joliot & S. Vriz (2020).
Commun. Biol.; https://pubmed.ncbi.nlm.nih.gov/32994473/
Otx2 signals from the choroid plexus to regulate adult neurogenesis. A. Planques, V. Oliveira Moreira, C. Dubreuil, A. Prochiantz & A.A. Di Nardo. (2019)
eNeuro; https://pubmed.ncbi.nlm.nih.gov/34445655/
Engrailed-1 induces long-lasting behavior benefit in an experimental Parkinson primate model. N. Thomasson, E. Pioli, C. Friedel, A. Monseur, J. Lavaur, K. L. Moya, E Bezard, A. Bousseau & A. Prochiantz (2019).
Mov.Dis.; https://doi.org/10.1002/mds.27714
Homeoprotein Neuroprotection of Embryonic Neuronal Cells. S.E. Vargas Abonce, M. Leboeuf, A. Prochiantz, & K.L. Moya (2019).
eNeuro; https://pubmed.ncbi.nlm.nih.gov/31451602/
Non-cell autonomous Otx2 homeoprotein regulates visual cortex plasticity through GADD45b. J. Apulei, N. Kim, D. Testa, J. Ribot, C. Bernard, A.A. Di Nardo & A. Prochiantz (2019).
Cereb.l Cortex. https://pubmed.ncbi.nlm.nih.gov/29771284/
Engrailed homeoprotein blocks degeneration in adult dopaminergic neurons through LINE-1 repression. F.-X. Blaudin de Thé, H. Rekaik, E. Peze-Heidsieck, O. Massiani-Beaudoin, R.L. Joshi, J. Fuchs & A. Prochiantz (2018).
EMBO J.; https://pubmed.ncbi.nlm.nih.gov/29941661/
Genetic Otx2 mis-localization delays critical period plasticity across brain regions. H.H.C. Lee, C. Bernard, Z.Y. MA, D. Acampora, A. Simeone, A. Prochiantz, A.A. DI Nardo & T.K. Hensch (2017).
Mol. Psy.; https://doi.org/10.1038/mp.2017.1
A mouse model for conditional secretion of specific single-chai antibodies provides genetic evidence for regulation of cortical plasticity by a non-cell autonomous homeoprotein transcription factor. C. Bernard, C. Vincent, D. Testa, E. Bertini, J. Ribot, A.A. Di Nardo, M. Volovitch & A. Prochiantz (2016).
PLOS Gen.; https://pubmed.ncbi.nlm.nih.gov/27171438/
Progressive nigrostriatal terminal dysfunction and degeneration in the engrailed 1 heterozygous model of Parkinson’s disease. U. Nordström, G. Beauvais, A. Ghosh, B. Chakrapani, P. Sasidharan, M. Lundblad, J. Fuchs, R.L. Joshi, J.W. Lipton, A. Roholt, T.N. Feinstein, J.A. Steiner, M.L. Escobar, A. Prochiantz & P. Brundin (2015).
Neurobiol. Dis.; https://pubmed.ncbi.nlm.nih.gov/25281317/
Engrailed homeoprotein protects mesencephalic dopaminergic neurons from oxidative stress. H. Rekaik, F.-X. Blaudin de Thé, J. Fuchs, O. Massiani-Beaudoin, A. Prochiantz & R. Joshi (2015).
Cell Rep.; https://doi.org/10.1016/j.celrep.2015.08.076
Graded Otx2 activities demonstrate does-sensitive eye and retina phenotypes. C. Bernard, H.-T. Kim, R. Torero-Ibad, E.J. Lee, M. Simonutti, S. Picaud, D. Acampora, A. Simeone, A.A. Di Nardo, A. Prochiantz, K.L. Moya* & J.W. Kim (2014).
Hum. Mol. Gen.; https://pubmed.ncbi.nlm.nih.gov/24234651/
Choroid plexus-derived Otx2 homeoprotein constrains adult cortical plasticity. J. Spatazza, HHC Lee, AA Di Nardo, L. Tibaldi, A. Joliot, T. Hensch & A. Prochiantz (2013).
Cell Rep.; https://pubmed.ncbi.nlm.nih.gov/23770240/
Otx2 binding to perineuronal nets persistently regulates plasticity in the mature visual cortex. M. Beurdeley, J. Spatazza, H.H.C. Lee, S. Sugiyama, C. Bernard, A.A. Di Nardo, T.K. Hensch & A. Prochiantz (2012).
J. Neurosci.; https://pubmed.ncbi.nlm.nih.gov/22764251/
Engrailed proteins protect mouse midbrain dopaminergic neurons against mitochondrial complex I insults. D. Alvarez-Fisher, J. Fuchs, F. Castagner, O. Stettler, O. Massiani-Beaudoin, K.L. Moya, C. Bouillot, W.H. Oertel, A. Lombès, W. Faigle, R.L. Joshi, A. Hartmann & A. Prochiantz (2011).
Nat. Neurosci.; https://www.nature.com/articles/nn.2916
Reviews
Therapeutic value of homeoprotein signaling. AA. Di Nardo & A. Prochiantz (2024).
Frontiers in Neuroscience, https://doi.org/10.3389/fnins.2024.1359523
Unconventional secretion, gate to homeoprotein intercellular transfer. A. Joliot & A. Prochiantz (2022).
Frontiers in Cell and developmental Biology, https://doi.org/10.3389/fcell.2022.926421
Homeoprotein transduction in neurodevelopment and physiopathology. A.A. Di Nardo, A. Joliot & A. Prochiantz (2020).
Science Adv.; https://pubmed.ncbi.nlm.nih.gov/33115744/
Perineuronal nets in brain physiology and disease. D. Testa, A. Prochiantz & A.A. Di Nardo (2019).
Seminars in Cell and Developmental Biology; https://pubmed.ncbi.nlm.nih.gov/30273653/.
The physiology of homeoprotein transduction. A. Di Nardo, J. Fuchs, R.L. Joshi, K.L. Moya & A. Prochiantz (2018).
Phys. Rev.; https://pubmed.ncbi.nlm.nih.gov/30067157/
OTX2-PNN interaction to regulate cerebral cortex plasticity. C. Bernard & A. Prochiantz (2016).
Neural. plast.; https://pubmed.ncbi.nlm.nih.gov/26881132/
Homeoprotein signaling in the developing and adult nervous system. A. Prochiantz & A.A. Di Nardo (2015).
Neuron; https://pubmed.ncbi.nlm.nih.gov/25741720/
Dr. Michael Shelanski is a cell biologist and neuropathologist. He received his MD and PhD degrees from the University of Chicago and trained in Neuropathology at Albert Einstein College of Medicine. Subsequently he worked in the laboratories of Nobel Laureate Marshall Nirenberg at the NIH and Jean-Pierre Changeux at the Institute Pasteur. He was Associate Professor of Neuropathology at Harvard prior to assuming the Chair of Pharmacology at NYU in 1978. In 1987 he moved to Columbia as the Delafield Professor and Chairman of the Department of Pathology and Cell Biology. Together with Dr. Richard Mayeux he founded the NIH sponsored Alzheimer’s Disease Research Center at Columbia and served as its Director for almost 25 years. He is a member of numerous advisory and editorial boards and a member of the National Academy of Medicine and of the Association of American Physicians. Dr Shelanski has served as a member of Study Sections at the NIH, the Alzheimer’s Association, the ALS Association, and the Dystonia Association. He is the Past- President of the Scientific Advisory Board of the Institut du Cerveau (Paris Brain Institute) in France.
Leonard Van den Berg, Professor of neurology and holding a chair in experimental neurology of motor neuron diseases at the University Medical Center Utrecht in the Netherlands. He is also director of the Laboratory for Neuromuscular Disease, director of the Netherlands ALS Center and chairman of the European Network to Cure ALS (ENCALS), a network of the European ALS Centers dedicated to clinical trials. A major emphasis of his research has been in ALS and other motor neuron disorders, and he has been a principal investigator on numerous drug trials in that field.
Takao Hensch, now Professor at Harvard University (USA) and University of Tokyo (JP), is one of the main academic players in the field of cerebral cortex plasticity. He has reported in a seminal paper (Science 1998) that a local GABA circuit controls experience-dependent plasticity in the developing visual system. It is in this context that he started to collaborate with Prof. Prochiantz leading to the discovery that the OTX2 homeoprotein internalized by a subpopulation of inhibitory interneuron is necessary and sufficient to open plasticity at P20 in the visual cerebral cortex and close it at P40. This study published in Cell in 2008 has opened new avenues for our understanding of how plasticity in the cerebral cortex is regulated and can be manipulated, not only in the visual system, but throughout the cortex, including regions that control mood and cognition. His work has been cited more than 20,000 times with H-index of 59 (Google scholar). He was awarded the 2016 Mortimer D. Sackler M.D. Prize for Distinguished Achievements in Developmental Psychobiology. “How Early Life Experience Shapes Brain Functions”.
Stéphane Palfi, Professor of Neurosurgery and Head of the Neurosurgery Department at Henri Mondor Medical center, Paris University (UPEC). His focus is on the development of surgical therapies for PD, Huntington disease, Tremor, Dystonia, and Psychiatric disorders. He has worked extensively around electrical neuromodulation of the brain in movement disorders, gene therapy for PD, cell grafting for Huntington and PD, as well as primate models of neurodegenerative disorders. He is a principal investigator on numerous preclinical and clinical studies and has been involved in studies of many novel agents including implanted brain devices, trophic factors GDNF, CNTF and lentiviral vectors Prosavin.
Before joining Turenne Capital in 2014, Bervin Bouani spent six years as an Asset Manager within the investment department at SHAM, an insurer specialized in healthcare companies’ risks. At SHAM, Bervin was in charge of risky assets (listed equities, Hedge Funds and private equity) and in particular was involved in the development of the private equity business (€ 30 million invested in 15 companies, including Adocia).
Benoit Barteau is Principal in the Life Sciences Department of BpifranceInvestissement. Since 2014, he has been involved in a dozen investment deals and current board member positions include Dynacure, Alentis and Igyxos. Prior, he gained experience in various biotech roles, co-discovered a vaccine candidate, developed an antibody production service.
From 2005 to 2015, Alexia was Partner and Head of Healthcare at Omnes Capital. She co-headed the management of the 26 innovative funds in venture capital.
Anne Bousseau has an extensive experience in drug development. During her 25+ years in the Sanofi-Aventis group, Anne Bousseau has held multiple senior positions all along the drug value chain, from leading a discovery group in the early days of HIV research to developing and registering oncology molecules such as cabazitaxel/ Jevtana in advanced metastatic prostate cancer.
Claire Friedel has a 20+ years of experience in the pharmaceutical industry, with various operational responsibilities in Medical Affairs for CNS drugs, focusing on the fields of Epilepsy and Parkinson Disease (Janssen-Cilag, UCB Pharma).
Prof. Alain Prochiantz PhD, has dedicated his entire career to study, alone or in collaboration with prestigious academics (Christine Holt, Cambridge, UK; Takao Hensch, Harvard, USA; Wolfgang Wurst, Humboldt Laboratory, Munich; Michael Shelanski, Columbia University, New York…) the numerous functions of HP signaling, primarily, but not only, in the developing and adult nervous system. A former student of the Ecole Normale Supérieure (ENS Paris),with a PhD thesis at the Faculty of Sciences René Diderot (Paris, FR) and MIT (Cambridge, USA) on the structure of plant messenger RNAs.