SCIENTIFIC PUBLICATIONS

Articles

2025

ALS driven by mutant NEK1 aggregation is accelerated by Pml loss, but clinically reversed through pharmacologic induction of Pml-mediated degradation. P. Georgiadou, B. Erkaya, M. Kawakita, E. Sahin, H. Öztürk, F. Tiryaki, K. Yildiz, I. Özgenç, E. Pekbilir, S. Anil Dogan, V. Lallemand-Breitenbach, S. Vargas, A. Prochiantz, E. Nur Firat-Karalar, H. de Thé, U. Sahin (2025).
bioRXiv ;https://doi.org/10.1101/2024.11.23.622051

Motor recovery through perineuronal net modulation in a Parkinson’s Disease mouse model.
D. Benacom, C. Chataing, A. Prochiantz, A.A. Di Nardo (2025).
Brain, in press; https://doi.org/10.1093/brain/awaf226

2023

Plasticity state-dependent changes in visual cortex parvalbumine interneuron mRNA translation and chromatin.
D. Benacom, C. Chataing, J. Apulei, I. Queguiner, A. Prochiantz & A.A. Di Nardo (2023).
bioRxiv; https://doi.org/10.1101/2023.09.11.557035

2022

ENGRAILED-1 transcription factor exerts a paracrine neurotrophic activity on adultspinalord α-motoneurons.
M. Lebœuf, S.E. Vargas-Abonce, E.Pezé-Hedsieck, E. Dupont,Jimenez-Alonso, K. L. Moya & Alain Prochiantz (2022).
bioR; https://doi.org/10.1101/2022.08.16.504081

2021

Perturbed DNA methylation by Gadd45b induces chromatin disorganization, DNA strand breaks and dopaminergic neuron death.
C. Ravel-Godreuil, O. Massiani-Beaudouin, P. Mailly, A. Prochiantz, R.L. Joshi & J. Fuchs (2021).
iScience; https://doi.org/10.1016/j.isci.2021.102756

Choroid plexus APP regulates adult brain proliferation and animal behavior.
K. Arnaud, V. Oliveira Moreira, J. Vincent, G. Dallerac, C. Le Poupon, M. Richter, U.C. Müller, L. Rondi-Reig, A. Prochiantz & A. Di Nardo (2021).
Life Sci. All.; https://pubmed.ncbi.nlm.nih.gov/34544751/

Non-cell autonomous OTX2 transcription factor regulates anxiety-related behaviors in the mouse. C. Vincent, J. Gilabert-Juan, D. Alvarez-Fischer, M.O. Krebs, G. Le Pen, A. Prochiantz & AA. Di Nardo (2021).
Mol.Psych.; https://pubmed.ncbi.nlm.nih.gov/33963285/

Diurrnal changes in perineuronal nets and parvalbumin neurons in rat prefrontal cortex. Brain structure and Function. J.H. Harkness, A.E. Gonzales, P.N. Bushana, E.T. Jorgensen, D.M. Hegarty, A.A. Di Nardo, A. Prochiantz, J.P. Wisor, S.A. Aicher, T.E. Brown & B.A. Sorg (2021).
Brain Struct. and Funct.; https://link.springer.com/article/10.1007/s00429-021-02229-4

Photoreceptor cKO of OTX2 enhances OTX2 intercellular transfer in the retina and causes photophobia. P. Pensieri, A. Mantilleri, D. Plassard, T. Furukawa, K.L. Moya, A. Prochiantz & T. Lamonerie (2021).
eNeuro;  https://doi.org/10.1523/ENEURO.0229-21.2021

OTX2 stimulates adult retinal ganglion cell cell regeneration. R. Torero-Ibad, N. Quenech’du, A. Prochiantz & K.L. Moya (2021).
Neur. Regen. Res;  https://doi.org/10.4103/1673-5374.320989

2020

Extracellular Pax6 regulates tangential Cajal-Retzius cell migration in the developing mouse neocortex. H. Kaddour, E. Coppola, A. A. Di Nardo, A. Wizenmann, M. Volovitch, A. Prochiantz & A. Pierani (2020).
Cereb. Cortex;  https://doi.org/10.1093/cercor/bhz098

OTX2 non-cell autonomous activity regulates inner retinal function. R. Torero-Ibad, B. Mazhar, C. Vincent, C. Bernard, J. Dégardin, M. Smonutti, T. Lamonerie, A.A. Di Nardo, A. Prochiantz & K.L. Moya (2020).
eNeuro; https://doi.org/10.1523/ENEURO.0012-19.2020

H2O2 and Engrailed 2 paracrine activity synergize to shape the zebrafish optic tectum. I. Amblard, M. Thauvin, C. Rampon, V.V. Park, A. Prochiantz, M. Volovitch, A. Joliot & S. Vriz (2020).
Commun. Biol.; https://pubmed.ncbi.nlm.nih.gov/32994473/

2019

Otx2 signals from the choroid plexus to regulate adult neurogenesis. A. Planques, V. Oliveira Moreira, C. Dubreuil, A. Prochiantz & A.A. Di Nardo. (2019)
eNeuro; https://pubmed.ncbi.nlm.nih.gov/34445655/

Engrailed-1 induces long-lasting behavior benefit in an experimental Parkinson primate model. N. Thomasson, E. Pioli, C. Friedel, A. Monseur, J. Lavaur, K. L. Moya, E Bezard, A. Bousseau & A. Prochiantz (2019).
Mov.Dis.; https://doi.org/10.1002/mds.27714

Homeoprotein Neuroprotection of Embryonic Neuronal Cells. S.E. Vargas Abonce, M. Leboeuf, A. Prochiantz, & K.L. Moya (2019).
eNeuro; https://pubmed.ncbi.nlm.nih.gov/31451602/

Non-cell autonomous Otx2 homeoprotein regulates visual cortex plasticity through GADD45b. J. Apulei, N. Kim, D. Testa, J. Ribot, C. Bernard, A.A. Di Nardo & A. Prochiantz (2019).
Cereb.l Cortex. https://pubmed.ncbi.nlm.nih.gov/29771284/

2018

Engrailed homeoprotein blocks degeneration in adult dopaminergic neurons through LINE-1 repression. F.-X. Blaudin de Thé, H. Rekaik, E. Peze-Heidsieck, O. Massiani-Beaudoin, R.L. Joshi, J. Fuchs & A. Prochiantz (2018).
EMBO J.;  https://pubmed.ncbi.nlm.nih.gov/29941661/

2017

Genetic Otx2 mis-localization delays critical period plasticity across brain regions. H.H.C. Lee, C. Bernard, Z.Y. MA, D. Acampora, A. Simeone, A. Prochiantz, A.A. DI Nardo & T.K. Hensch (2017).
Mol. Psy.;  https://doi.org/10.1038/mp.2017.1

2016

A mouse model for conditional secretion of specific single-chai antibodies provides genetic evidence for regulation of cortical plasticity by a non-cell autonomous homeoprotein transcription factor. C. Bernard, C. Vincent, D. Testa, E. Bertini, J. Ribot, A.A. Di Nardo, M. Volovitch & A. Prochiantz (2016).
PLOS Gen.;  https://pubmed.ncbi.nlm.nih.gov/27171438/

2015

Progressive nigrostriatal terminal dysfunction and degeneration in the engrailed 1 heterozygous model of Parkinson’s disease. U. Nordström, G. Beauvais, A. Ghosh, B. Chakrapani, P. Sasidharan, M. Lundblad, J. Fuchs, R.L. Joshi, J.W. Lipton, A. Roholt, T.N. Feinstein, J.A. Steiner, M.L. Escobar, A. Prochiantz & P. Brundin (2015).
Neurobiol. Dis.;  https://pubmed.ncbi.nlm.nih.gov/25281317/

Engrailed homeoprotein protects mesencephalic dopaminergic neurons from oxidative stress. H. Rekaik, F.-X. Blaudin de Thé, J. Fuchs, O. Massiani-Beaudoin, A. Prochiantz & R. Joshi (2015).
Cell Rep.;  https://doi.org/10.1016/j.celrep.2015.08.076

2014

Graded Otx2 activities demonstrate does-sensitive eye and retina phenotypes. C. Bernard, H.-T. Kim, R. Torero-Ibad, E.J. Lee, M. Simonutti, S. Picaud, D. Acampora, A. Simeone, A.A. Di Nardo, A. Prochiantz, K.L. Moya* & J.W. Kim (2014).
Hum. Mol. Gen.;  https://pubmed.ncbi.nlm.nih.gov/24234651/

2013

Choroid plexus-derived Otx2 homeoprotein constrains adult cortical plasticity. J. Spatazza, HHC Lee, AA Di Nardo, L. Tibaldi, A. Joliot, T. Hensch & A. Prochiantz (2013).
Cell Rep.;  https://pubmed.ncbi.nlm.nih.gov/23770240/

2012

Otx2 binding to perineuronal nets persistently regulates plasticity in the mature visual cortex. M. Beurdeley, J. Spatazza, H.H.C. Lee, S. Sugiyama, C. Bernard, A.A. Di Nardo, T.K. Hensch & A. Prochiantz (2012).
J. Neurosci.; https://pubmed.ncbi.nlm.nih.gov/22764251/

2011

Engrailed proteins protect mouse midbrain dopaminergic neurons against mitochondrial complex I insults. D. Alvarez-Fisher, J. Fuchs, F. Castagner, O. Stettler, O. Massiani-Beaudoin, K.L. Moya, C. Bouillot, W.H. Oertel, A. Lombès, W. Faigle, R.L. Joshi, A. Hartmann & A. Prochiantz (2011).
Nat. Neurosci.; https://www.nature.com/articles/nn.2916